DeNova Sciences offers services for validation/testing/development of dermatological products using our established in vitro skin models as a standardized testing platform, variability in the analysis and interpretations are greatly reduced. Specific areas/fields of DeNova Sciences expertise include Dermatological Studies and Material Tissue Engineering.
DeNova Sciences offers Laser Capture Microdissection (LCM) & microarray services for difficult paraffin-embedded (FFPE) or cryo preserved samples. We also provide basic preparation of histology work and microscopy imaging services
“ Ingredients have to reach their ideal penetration depth to serve their purpose.
“The ingredient first has to get to the targeted area in the skin before performing its magic”
“Delivery systems are often designed to assist the optimal release of active ingredients”
“hyperproliferative pathophysiologic process in psoriasis”
“Quantitating and viability testing of cells.”
Normal cells do not divide indefinitely due to a process termed cellular or replicative senescence, thus a well-controlled programmed cell death can kick start the cellular renewal mechinary.
“Extensive cell death often leads to skin inflammation.’”
“Exposure of sample to different time course and dosage are possible”
Free radicals and reactive oxygen species (ROS) are highly reactive molecules that are generated by normal cellular processes upon environmental stresses. ROS reacts with cellular components hence damaging DNA, carbohydrates, proteins, lipids from extracts and synthetic chemicals leading to cellular and tissue injury.
Excess production of reactive oxygen species can also lead to inflammation, premature aging, and several clinical disease states, including cancer, diabetes, and atherosclerosis.
External stimuli such as anti-oxidant formulations can allow tissues to sustain their complex antioxidant system by protecting themselves from oxidative stress, however, excess ROS can overwhelm the systems and cause severe damage.
“To achieve a balance between oxidant and antioxidant effects in the tissue.”
To study the different environmental effects (Temperature, moisture, etc) on the life time of product.
DeNova sciences offers gene expression profiling services through our microarray service. This service is offered to assist researchers with studies on gene expression profiling from specific regions or population of cells. We use the Laser Capture Micro-dissection to cut and collect the samples from slides using the Arcturus system. DeNova sciences uses compatible and validated procedures for the full array services which guarantee the good data quality and fast turn-over time.
Description of services
*Quantification and estimating RNA purity using a NanoDrop spectrophotometer
Service prices are dependent on set up and sample volume.
Contact us for more info at firstname.lastname@example.org.